In this episode of the Longevity Podcast, I sit down with biomedical engineer and longevity entrepreneur Courtney Van Bussum to unpack the real science behind NAD+ metabolism and why the current obsession with boosting NAD+ through supplements, infusions, and precursors may be missing a critical piece of the puzzle. We explore the complex biology behind NAD+, NADH balance, the salvage pathway, and the role of enzymes like CD38 and NNMT in regulating cellular energy, inflammation, and aging. Courtney explains why simply increasing NAD+ levels isn’t always beneficial—and how pushing the system too hard can actually disrupt cellular balance.
We also dive into the hidden role of methylation in NAD metabolism, why many people may not respond well to common precursors like NMN and NR, and the emerging science behind molecules such as 1-MNA that may support microvascular health, nitric oxide production, mitochondrial function, and metabolic resilience. We discuss practical strategies for protecting your NAD system through sleep, circadian rhythm, exercise, ketones, and metabolic health, as well as the limitations of current NAD testing and biomarkers. If you want to intelligently optimize energy, immunity, and longevity—without falling for the hype—this episode will change the way you think about NAD+ supplementation. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout. 🔹 What you will learn: → Why simply boosting NAD+ with NMN, NR, or IV infusions may not work—and how it can actually disrupt your NAD⁺/NADH balance → The hidden role of methylation, CD38, and NNMT enzymes in NAD metabolism—and why these factors determine whether supplementation helps or harms → How emerging molecules like 1-MNA, along with sleep, circadian rhythm, exercise, and ketones, can support cellular energy, mitochondrial health, and longevity
